is coimmunoprecipitation alone enough

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is coimmunoprecipitation alone enough

SL-3
Hi,

I am reading publications, and find that, people usually do Co-IP, or
pulldown assays to confirm their yeast-two-hybrid result, but not many
people do yeast two hyb to confirm co-IP results. I am just wondering,
is co-IP itself alone enough to prove protein-protein interaction?

Thanks.

S
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