A set of 15 proteins found in urine can distinguish healthy
individuals from those who have coronary artery disease (CAD), a new
study has found.
Due to the ease of obtaining samples, urinary protein analysis is
emerging as a powerful tool to detect and monitor disease. Anna
Dominiczak and colleagues tested whether urine could provide useful
biomarkers for coronary disease, one of the leading worldwide killers.
They analyzed samples from 88 CAD patients and 282 controls and found
a 15 protein "signature" indicative of disease. Several of the protein
fragments were collagens, which are components of arterial walls.
The researchers next examined how predictive their protein panel was
and found it could identify the presence of CAD 83% of the time. The
panel had a sensitivity of over 98%, which means the test produced
almost no false positives and thus inaccuracies are primarily
misdiagnosing CAD individuals as healthy. The researchers also
observed that the protein signatures of CAD individuals became more
normal after exercise, suggesting these biomarkers can be used to both
help diagnose CAD and monitor the progress of treatment
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